Covid19 vaccine begins human trials stage at Oxford University
Covid19 vaccine begins human trials stage at Oxford University:-
Clinical trials on human being subjected a new corona virus vaccine got under way at Oxford University on 23rd April,2020.
Scientists present in a lab at one of the world's to universities have an goal of preparing vaccine as soon as possible.
All over the world more than 100 research projects are being conducted to find a vaccine.
Support from British Government:-
The British Government strongly supports the Oxford University's work & the first human trials were subjected to past Thursday.
Health minister of Britain said about the promising development pointing out that it would normally take years to reach such a stage of vaccine development.
Financial gamble:-
The strategy of not waiting for each step to be completed before launching production is a financial "gamble", according to Nicola Stonehouse, professor of molecular virology at the University of Leeds.
But the current crisis makes it a necessary gamble, she told AFP.
The Oxford vaccine is based on a chimpanzee adenovirus, which is modified to produce proteins in human cells that are also produced by COVID-19.
It is hoped the vaccine will teach the body's immune system to then recognise the protein and help stop the coronavirus from entering human cells.
The adenovirus vaccine is known to develop a strong immune response with a single dose and is not a replicating virus, so cannot cause infection, making it safer for children, the elderly and patients with underlying diseases such as diabetes.
What does study involves??
Upto 1102 volunteers will be selected across multiple sites in Oxford, London and other cities.
These volunteers will be randomly allocated to receive either the CoVid-19 vaccine or the licensed vaccine that will be used as a control for comparison.
How will the human trial work??
The main aim is to find out whether the vaccine is going to work against COVID 19, if it didn't cause unacceptable side effects,& if induces good immune responses.
The first few days of the trials will be planned as follows:-
Day1:
First two participants will be vaccinated one with COVID 19 vaccine and other with the control vaccine.
Volunteers examine for 48 hours.
Day3:
Six volunteers will be vaccinated three with COVID 19 vaccine and three other will with the control vaccine.
Volunteers examine for 48 hours.
Day5:
Progress to vaccinating Largee number of volunteers.
How long will the results will available??
A high proportion of vaccines are found not to be promising even before clinical trials.
If the vaccine is unable to show the protective response COVID 19, they will review their processing & examine others alternatives approaches like different number of doses.
What are the upcoming steps??
They are planning to vaccinate 800 volunteers in the UK over next month. If the trial is successful in UK they will move towards Kenya government for permission to evaluate in Kenya.
Failure oF human clinical trials in China:-
Human trials have started in at least seven places around the world, including Seattle in the US and in Shanghai, China. But other research in China reportedly showed that the drug remdesivir flopped as a potential treatment for Covid-19 patients.
Clinical trials on human being subjected a new corona virus vaccine got under way at Oxford University on 23rd April,2020.
Scientists present in a lab at one of the world's to universities have an goal of preparing vaccine as soon as possible.
All over the world more than 100 research projects are being conducted to find a vaccine.
Support from British Government:-
Health minister of Britain said about the promising development pointing out that it would normally take years to reach such a stage of vaccine development.
Financial gamble:-
The strategy of not waiting for each step to be completed before launching production is a financial "gamble", according to Nicola Stonehouse, professor of molecular virology at the University of Leeds.
But the current crisis makes it a necessary gamble, she told AFP.
The Oxford vaccine is based on a chimpanzee adenovirus, which is modified to produce proteins in human cells that are also produced by COVID-19.
It is hoped the vaccine will teach the body's immune system to then recognise the protein and help stop the coronavirus from entering human cells.
The adenovirus vaccine is known to develop a strong immune response with a single dose and is not a replicating virus, so cannot cause infection, making it safer for children, the elderly and patients with underlying diseases such as diabetes.
What does study involves??
Upto 1102 volunteers will be selected across multiple sites in Oxford, London and other cities.
These volunteers will be randomly allocated to receive either the CoVid-19 vaccine or the licensed vaccine that will be used as a control for comparison.
How will the human trial work??
The main aim is to find out whether the vaccine is going to work against COVID 19, if it didn't cause unacceptable side effects,& if induces good immune responses.
The first few days of the trials will be planned as follows:-
Day1:
First two participants will be vaccinated one with COVID 19 vaccine and other with the control vaccine.
Volunteers examine for 48 hours.
Day3:
Six volunteers will be vaccinated three with COVID 19 vaccine and three other will with the control vaccine.
Volunteers examine for 48 hours.
Day5:
Progress to vaccinating Largee number of volunteers.
How long will the results will available??
A high proportion of vaccines are found not to be promising even before clinical trials.
If the vaccine is unable to show the protective response COVID 19, they will review their processing & examine others alternatives approaches like different number of doses.
What are the upcoming steps??
They are planning to vaccinate 800 volunteers in the UK over next month. If the trial is successful in UK they will move towards Kenya government for permission to evaluate in Kenya.
Failure oF human clinical trials in China:-
Human trials have started in at least seven places around the world, including Seattle in the US and in Shanghai, China. But other research in China reportedly showed that the drug remdesivir flopped as a potential treatment for Covid-19 patients.
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